"If you were guaranteed honest responses to three questions, who would you question and what would you ask?"
I have a million I could do in my personal life, but they wouldn't mean anything here...so I'm going to keep this in the political/pop culture realm.
1) Ask President Clinton if he did indeed rape Juanita Broaddrick.
2) Ask President Bush if the government had ANY part in 9/11 (then the conspiracy people would have to shut up).
3) Ask Robert S. Mueller (director of the FBI) the juiciest secret the public doesn't know but the FBI does.